HSP90α-IN-1

HSP90α-IN-1 is a HSP90α inhibitor (IC50 = 111 nM) that exhibits senolytic activity across various cellular senescence models. HSP90α-IN-1 is related to the xanthinic family. HSP90α-IN-1 is involved in research on combating age-related inflammaging and diseases, including cancer, and possibly extend a healthy lifespan[1].

Product Specifications

CAS Number

[184897-90-3]

UNSPSC

12352005

Target

HSP; Interleukin Related

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N1CC2=CC=CC=C2)N(C3=CC=CC=C3C)C4=C(NC=N4)C1=O

Molecular Formula

C19H16N4O2

Molecular Weight

332.36

References & Citations

[1]Atlante S, et al., A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties. Aging Cell. 2025 Mar 17:e70047.