HMAO-B-IN-11

HMAO-B-IN-11 (Compound 12) is a selective and reversible inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 0.11 µM. hMAO-B-IN-11 acts through competitive binding to the hMAO-B active site, preventing oxidative deamination of monoamines and reducing hydrogen peroxide production. hMAO-B-IN-11 also inhibits pro-inflammatory mediators (NO, TNF-α, IL-1β) in activated microglia, hMAO-B-IN-11 is promising for research of neurodegenerative diseases like Parkinson’s and Alzheimer’s[1].

Product Specifications

UNSPSC

12352100

Target

Interleukin Related; Monoamine Oxidase; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CC=C(Cl)S1)/C=C/C2=CC=C3OCCOC3=C2

Molecular Formula

C15H11ClO3S

Molecular Weight

306.76

References & Citations

[1]Sun D, et al. 1, 4-benzodioxan-substituted Thienyl chalcone derivatives as novel reversible inhibitors of human monoamine oxidase B with anti-neuroinflammatory activity. Sci Rep. 2025 Mar 13;15 (1) :8690.