PROTAC SMARCA2/4 degrader-38

PROTAC SMARCA2/4 degrader-38 is a degrader SMARCA2/4 PROTAC (DC50: 3.0 nM and 4.0 nM respectively) . PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078) ; Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343) ) [1].

Product Specifications

CAS Number

[3081688-77-6]

UNSPSC

12352005

Target

Apoptosis; Epigenetic Reader Domain; PROTACs

Related Pathways

Apoptosis; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.46

Smiles

O=C([C@H]1N(C([C@@H](NC(C2(C3=CC=C(C4=CC(C5=CC=CC=C5O)=NN=C4N)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C

Molecular Formula

C43H47N7O5S

Molecular Weight

773.94

References & Citations

[1]Yang T, et al. Design, synthesis and biological evaluation of 3-amino-6- (2-hydroxyphenyl) pyridazin-4-aryl derivatives as SMARCA2/4 degraders. Eur J Med Chem. 2025 Jun 5;290:117521.