15-LOX-1 inhibitor 2
15-LOX-1 inhibitor 2 (Compound 5i) is an inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 of 1.7 μM. 15-LOX-1 inhibitor 2 inhibits the activity of 15-LOX-1 enzyme, reduces the production of lipid peroxides, thereby inhibiting lipid peroxidation and protecting cells from cell death induced by RSL3 (HY-100218A) . 15-LOX-1 inhibitor 2 can be used in research on cell death mechanisms, oxidative stress-related diseases and other fields[1].
Product Specifications
UNSPSC
12352005
Target
LOX-1
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
CCCCCCCNCC1=C(C2=CC=CC=C2)NC3=CC(Cl)=CC=C31
Molecular Formula
C22H27ClN2
Molecular Weight
354.92
References & Citations
[1]Zhang J, et al. Novel 15-lipoxygenase-1 inhibitor protects cells from RSL3-induced cell death. Eur J Med Chem. 2025 Jun 5;290:117517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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