Antitumor agent-201

Antitumor agent-201 (Compound 10) is a chloride transport activator that targets the Golgi apparatus. Its EC50 for promoting the transmembrane transport of chloride ions is 1.53 mol%, and its IC50 against HepG2 cells is 7.13 μM. Antitumor agent-201 exerts its anti-cancer activity by selectively acting on the Golgi apparatus, disrupting the chloride ion homeostasis within it, reducing the expression of key proteins such as GM130 and GRASP55, altering the structure and function of the Golgi apparatus, triggering Autophagy of the Golgi apparatus, and further inducing Apoptosis of cancer cells and arresting cancer cells in the G2/M phase. Antitumor agent-201 can be used in the research field of cancer diseases[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; Chloride Channel

Related Pathways

Apoptosis; Autophagy; Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

O=S(C1=CC=C(NC(CCCCCNC2=C(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C(C2=O)=O)=O)C=C1)(N)=O

Molecular Formula

C24H22F6N4O5S

Molecular Weight

592.51

References & Citations

[1]Yang H, et al. Design, synthesis and biological evaluation of Golgi-targeting anion transporters as inducers of Golgiphagy and apoptosis in cancer cells. Eur J Med Chem. 2025 Jun 5;290:117519.