HDAC-IN-89
HDAC-IN-89 is an inhibitor of HDAC1 (IC50: 0.95 nM), HDAC2 (IC50: 0.86 nM), HDAC3 (IC50: 1.06 nM) and HDAC8 (IC50: 4.24 nM) . HDAC-IN-89 blocks the cell cycle and induces apoptosis. HDAC-IN-89 has anti-tumor activity[1].
Product Specifications
UNSPSC
12352211
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CC(C)[C@@H](C(N[C@H](/C=C/CCSSC[C@@H](C1=O)NC2=O)C(F)(F)C(N[C@@H]2C(C)C)=O)=O)NC(/C(N1)=C/C)=O
Molecular Formula
C24H35F2N5O5S2
Molecular Weight
575.69
References & Citations
[1]Song X, et al. Synthesis and biological evaluation of the Fluoro analog of Romidepsin with improved selectivity for class I histone deacetylases (HDACs) . Bioorg Chem. 2025 Mar 13;159:108348.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Curated Selection
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