STING-IN-14

STING-IN-14 is an inhibitor of STING (IC50: 0.6 nM) . STING-IN-14 inhibits the activation of the IRF pathway in THP1-DualTM cells. STING-IN-14 can be used in autoimmune diseases research[1].

Product Specifications

CAS Number

[3070953-78-2]

UNSPSC

12352005

Target

STING

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

[H][C@]1(C(NC[C@@H](C(NCC2=CC=CC=C2)=O)NC([C@]3([H])C[C@@](O4)([H])CN3C5=NC=NC6=C5C=NN6C7=C(F)C=C(F)C=C7)=O)=O)N(CCN8N=C(C=CC=C9C%10=CC=CC4=C%10)C9=C8)CCOC1

Molecular Formula

C46H43F2N11O5

Molecular Weight

867.90

References & Citations

[1]1. Han X, et al. Macrocycles for the treatment of autoimmune disease and their preparation. WO2025021666. F. Hoffmann-La Roche AG, Switzerland. 2025-01-30.