STING-IN-14
STING-IN-14 is an inhibitor of STING (IC50: 0.6 nM) . STING-IN-14 inhibits the activation of the IRF pathway in THP1-DualTM cells. STING-IN-14 can be used in autoimmune diseases research[1].
Product Specifications
CAS Number
3070953-78-2
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
[H][C@]1(C(NC[C@@H](C(NCC2=CC=CC=C2)=O)NC([C@]3([H])C[C@@](O4)([H])CN3C5=NC=NC6=C5C=NN6C7=C(F)C=C(F)C=C7)=O)=O)N(CCN8N=C(C=CC=C9C%10=CC=CC4=C%10)C9=C8)CCOC1
Molecular Formula
C46H43F2N11O5
Molecular Weight
867.90
References & Citations
[1]1. Han X, et al. Macrocycles for the treatment of autoimmune disease and their preparation. WO2025021666. F. Hoffmann-La Roche AG, Switzerland. 2025-01-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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