PAD4-IN-5
PAD4-IN-5 (Example 18) is a PAD4 inhibitor with IC50s of ≤10 nM and 101-500 nM for human PAD4 (hPAD4) under 50 µM Ca2+ and 1 mM Ca2+ conditions, respectively. PAD4-IN-5 can be used for the study of autoimmune disease, such as rheumatoid arthritis (RA) [1].
Product Specifications
CAS Number
[3071873-52-1]
UNSPSC
12352005
Target
Protein Arginine Deiminase
Related Pathways
Epigenetics
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(C=C(N(C)C(C3=CC4=C(N=C([C@H](N5)C)C=C4)N3CCCCC[C@@H]6C[C@H]6C5=O)=N7)C7=C2)CCN1C[C@H]8COCCN8
Molecular Formula
C34H41N7O3
Molecular Weight
595.73
References & Citations
[1]Makonen Belema, et al. Heterocyclic pad4 inhibitors. WO2025024288A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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