HEMTAC WEE1 degrader-1

HEMTAC WEE1 degrader-1 is a HSP90-mediated targeting chimera (HEMTAC) degrader of WEE1 (HSP90 enzyme inhibitory activity is IC50: 16.76 nM) . HEMTAC WEE1 degrader-1 promotes the ubiquitination and degradation of WEE1. HEMTAC WEE1 degrader-1 blocks the G2/M cell cycle. HEMTAC WEE1 degrader-1 has anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft (PDX) models. HEMTAC WEE1 degrader-1 can be used in AML research. (Pink: HSP90 binder; Blue: WEE1 ligand; Black: linker) [1].

Product Specifications

CAS Number

[3002417-64-0]

UNSPSC

12352005

Target

HSP; Wee1

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.7800

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC=C(CN4CCN(CC(NCCCCN5CCN(C6=CC=C(NC7=NC=C8C(N(C9=NC(C(C)(O)C)=CC=C9)N(CC=C)C8=O)=N7)C=C6)CC5)=O)CC4)C=C3)NCC

Molecular Formula

C57H71N15O6

Molecular Weight

1062.27

References & Citations

[1]Li X, et al. Design, synthesis and biological evaluation of WEE1 degraders via HSP90-mediated targeting chimeras for target therapy of acute myeloid leukemia. Eur J Med Chem. 2025 Jun 5;290:117512.