STING-IN-12
STING-IN-12 (compound Y2) is an inhibitor of STING. STING-IN-12 inhibits IFNβ gene expression (IC50=0.75μM) induced by SR717. STING-IN-12 inhibits STING pathway activation induced by the STING agonist SR717 in THP1 cells and MSA-2-induced STING pathway activation in vivo in mice[1].
Product Specifications
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC=C(OCCCC(F)(F)F)C=C1)C2=CC=C([N+]([O-])=O)O2
Molecular Formula
C15H13F3N2O5
Molecular Weight
358.27
References & Citations
[1]Liang Xue, et al. Design, synthesis, and activity evaluation of novel STING inhibitors based on C170 and H151. Eur J Med Chem. 2025 Jun 5:290:117533.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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