Pan-BET/BD2-IN-1
Pan-BET/BD2-IN-1 (compound 6b) is a selective extra-terminal (BET) protein inhibitor (BRDT-1 Ki = 1.05 μM and BRD4-1 Ki = 0.68 μM) . pan-BET/BD2-IN-1 inhibits MM.1S cancer cell growth with an IC50 of 2.6 μM[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=CC=C(C(OCCOC2=C(C=CC=C2)COC3=O)=C1)C4C3=C(NC(N(C(N5)=O)CC)=C4C5=O)C
Molecular Formula
C27H27N3O6
Molecular Weight
489.52
References & Citations
[1]Jiewei Jiang, et al. Macrocyclic dihydropyridine analogs as pan-BET BD2-preferred inhibitors. Eur J Med Chem. 2025 Jun 5:290:117504.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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