CDK2-IN-44

CDK2-IN-44 (Compound 46) is an inhibitor of cyclin-dependent kinase 2 (CDK2) . CDK2-IN-44 can effectively inhibit the proliferation of cancer cells and exert its activity in inhibiting cancer cell growth by arresting the cell cycle, promoting Apoptosis, and inducing cellular senescence. CDK2-IN-44 holds promise for use in the research of ovarian cancer and breast cancer[1].

Product Specifications

CAS Number

[3051587-93-7]

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

FC1=CC(C2=NC(NC3CCN(S(=O)(C4CC4)=O)CC3)=NC=C2F)=CN(C(CC)C)C1=O

Molecular Formula

C21H27F2N5O3S

Molecular Weight

467.53

References & Citations

[1]Chen W, et al. Discovery of potent and selective CDK2 inhibitors with high safety and favorable bioavailability for the treatment of cancer. Eur J Med Chem. 2025 Jun 5;290:117503.