CDK2-IN-44
CDK2-IN-44 (Compound 46) is an inhibitor of cyclin-dependent kinase 2 (CDK2) . CDK2-IN-44 can effectively inhibit the proliferation of cancer cells and exert its activity in inhibiting cancer cell growth by arresting the cell cycle, promoting Apoptosis, and inducing cellular senescence. CDK2-IN-44 holds promise for use in the research of ovarian cancer and breast cancer[1].
Product Specifications
CAS Number
3051587-93-7
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
FC1=CC(C2=NC(NC3CCN(S(=O)(C4CC4)=O)CC3)=NC=C2F)=CN(C(CC)C)C1=O
Molecular Formula
C21H27F2N5O3S
Molecular Weight
467.53
References & Citations
[1]Chen W, et al. Discovery of potent and selective CDK2 inhibitors with high safety and favorable bioavailability for the treatment of cancer. Eur J Med Chem. 2025 Jun 5;290:117503.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2
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