SEH inhibitor-20
SEH inhibitor-20 is an orally active and metabolically stable sEH inhibitor (IC50: 0.2 nM) . sEH inhibitor-20 has significant analgesic and anti-inflammatory activities and is expected to become a potential candidate compound for the study of neuropathic pain[1].
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1NN=C(C2=CC=C(NC(NCC3=CC=CC=C3OC(F)(F)F)=O)C=C2)C=C1
Molecular Formula
C19H15F3N4O3
Molecular Weight
404.34
References & Citations
[1]Lengerli D, et al. Phenyl-benzyl-ureas with pyridazinone motif: Potent soluble epoxide hydrolase inhibitors with enhanced pharmacokinetics and efficacy in a paclitaxel-induced neuropathic pain model. Eur J Med Chem. 2025 Jun 5;290:117510.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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