PDHK1-IN-3
PDHK1-IN-3 (Compound 29) is a selective PDHK1 inhibitor with an IC50 of 0.028 μM against PDHK1 and an IC50 of 0.120 μM against PDHK2. PDHK1-IN-3 inhibits the activity of PDHK1 by forming a covalent bond with Lys299 in PDHK1. PDHK1-IN-3 can be used in the research of autoimmune diseases, inflammatory diseases, and cancer[1].
Product Specifications
UNSPSC
12352005
Target
PDHK
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
CCNC1=C2C(N(C3=CC=C(OC4=CC=CC(S(=O)(F)=O)=C4)C=C3)C(N2)=O)=CC(F)=C1
Molecular Formula
C21H17F2N3O4S
Molecular Weight
445.44
References & Citations
[1]Xu et al. Discovery of ATP competitive PDHK1/2 dual inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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