PDHK1-IN-2
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 (PDHK1/2), with an IC50 of 0.007 μM for PDHK1 and an IC50 of 0.015 μM for PDHK2. PDHK1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions[1].
Product Specifications
CAS Number
[2870691-38-4]
UNSPSC
12352005
Target
PDHK
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
CCNC1=CC(F)=CC(C2(CC)N3CCC[C@@H](NC(C4CC5(CN(C#N)C5)C4)=O)C3)=C1NC2=O
Molecular Formula
C25H33FN6O2
Molecular Weight
468.57
References & Citations
[1]Xu H, et al. Discovery of ATP competitive PDHK1/2 dual inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Mouse Pulmonary Surfactant-Associated Protein A (SFTPA1) Protein
Mouse Pulmonary Surfactant-Associated Protein A (SFTPA1) Protein