MAGL-IN-222

MAGL-IN-222 (Compound ZQ-7) is a covalent inhibitor targeting monoacylglycerol lipase (MAGL) with an IC50 of 42.31 μM. MAGL-IN-222 can reduce the breakdown of 2-arachidonoylglycerol (2-AG) and increase the intracellular 2-AG level, thereby inhibiting the proliferation and migration of MDA-MB-231 breast cancer cells. MAGL-IN-222 can be used in the research of breast cancer and other related diseases[1].

Product Specifications

CAS Number

[877804-65-4]

UNSPSC

12352005

Target

Lipase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CC(/C(C(N1C2CCS(C2)(=O)=O)=O)=C/C3=CC=C(N(CC)CC)C=C3)=C(C#N)C1=O

Molecular Formula

C22H25N3O4S

Molecular Weight

427.52

References & Citations

[1]Wang J, et al. Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock. Bioorg Chem. 2025 Mar 15;159:108378.