ASK1-IN-8

ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM[1]. In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver[1]. ASK1-IN-8 can be used in research related to liver diseases[1].

Product Specifications

CAS Number

[2570985-89-4]

UNSPSC

12352005

Target

ASK1

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Smiles

CNC(C1CCN(C2=CC=C(N3C(N(C4=NC(C5=NN=CN5C(C)C)=CC=C4)CC3)=O)C=C2)CC1)=O

Molecular Formula

C26H32N8O2

Molecular Weight

488.58

References & Citations

[1]Rai SK, et al. Identification and evaluation of cyclic urea based 4H-triazolo pyridine substituted derivatives as novel ASK1 inhibitors. Bioorg Chem. 2025 Mar 14;159:108375.