PDE4D inhibitor 1
PDE4-IN-1 is a PDE4 inhibitor with high potency (IC50 : 8.6 nM) and selectivity over other PDE subtypes. PDE4-IN-1 inhibits the release of inflammatory cytokines and chemokines. PDE4-IN-1 greatly restores impaired cAMP-CREB signaling pathway. PDE4-IN-1 inhibits proliferation and promotes differentiation to reverse the formation of psoriasis[1].
Product Specifications
UNSPSC
12352005
Target
CXCR; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC([C@H]1C[C@@H](OC2=C3OC(C4=CC=C(OC(F)F)C(OCC5CC5)=C4)=CC3=CC=C2O)CN1)=O
Molecular Formula
C25H25F2NO7
Molecular Weight
489.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE2; PDE3; PDE4; PDE5; PDE7; PDE8; PDE9
Frequently Asked Questions
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