DDR1-IN-11
DDR1-IN-11 (Compound 4) is an inhibitor of Discoidin domain receptor 1 (DDR1) with an IC50 of 46.16 nM. DDR1-IN-11 can achieve an inhibition rate of 99.86% against Z-138 cells at a concentration of 10 μM, and it can be used in the research of acute myeloid leukemia (AML) [1].
Product Specifications
CAS Number
[639089-54-6]
UNSPSC
12352005
Target
Discoidin Domain Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1CC1)NC2=CC=C(C=C2)SC3=NC(N4CCN(CC4)C)=CC(NC5=NNC(C)=C5)=N3
Molecular Formula
C23H28N8OS
Molecular Weight
464.59
References & Citations
[1]Xia B, et al. Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking. Biomed J. 2021 Dec;44 (6 Suppl 1) :S15-S24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1
Curated Selection
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