Brefeldin A 4-O-nicotinate

Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC50 value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer[1].

Product Specifications

CAS Number

[3035018-34-6]

Product Name Alternative

CHNQD-01228

UNSPSC

12352005

Target

Arf Family GTPase; BMX Kinase

Related Pathways

GPCR/G Protein; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C1O[C@@H](C)CCC/C=C/[C@@]2([H])[C@](C[C@@H](O)C2)([H])[C@H](OC(C3=CN=CC=C3)=O)/C=C/1

Molecular Formula

C22H27NO5

Molecular Weight

385.45

References & Citations

[1]Liu JY, et al. Niacin Ester Derivative of Brefeldin A as a Potential Dual-Target Arf1/BMX Inhibitor for Bladder Cancer. J Nat Prod. 2025 Mar 28;88 (3) :830-841.