AIC263282

AIC263282 is a potent Hepatitis B Virus (HBV) capsid assembly modulator with an EC50 of 3.8 nM. AIC263282 shows an IC50 of 61 nM for hERG. AIC263282 exhibits activity against viral replication and hepatitis B surface antigen (HBsAG) on primary human hepatocytes[1].

Product Specifications

UNSPSC

12352005

Target

HBV; Potassium Channel

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Infection

Smiles

CCC1=C2C(NC(C(N3[C@H](C)CN(C(C(NC4(COC4)C)=O)=O)CC3)=O)=C2)=CC(F)=C1

Molecular Formula

C22H27FN4O4

Molecular Weight

430.47

References & Citations

[1]Bernhard Lesch, et al. Discovery of AIC263282, a Hepatitis B Virus Capsid Assembly Modulator Ready for Candidate Profiling. J Med Chem. 2025 Mar 27;68 (6) :6361-6371.