SARM1-IN-4
SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL) . SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.) .
Product Specifications
CAS Number
[3069378-18-0]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
C[C@@H](C1=CC=NC=C1)N(C(N[C@@H]2COCC2(F)F)=O)C
Molecular Formula
C13H17F2N3O2
Molecular Weight
285.29
References & Citations
[1]Giroud M, et al. Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy. J Med Chem. 2025 Mar 27;68 (6) :6558-6575.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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