PDGFRα kinase inhibitor 3
PDGFRα kinase inhibitor 3 (Compound L7) is a highly potent inhibitor targeting the PDGFRαD842V kinase with IC50s values of 23.8 nM and 2.1 nM in biochemical and cellular assays, respectively. PDGFRα kinase inhibitor 3 binds to the ATP-binding pocket of PDGFRαD842V to block its downstream signaling pathways and inhibit kinase activity. PDGFRα kinase inhibitor 3 can be used for gastrointestinal stromal tumors (GISTs) study[1].
Product Specifications
UNSPSC
12352005
Target
PDGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C1(N2C=NC3=C2C=C4C=C3)=CC=C5C(C(N6CCC(CC6)NCCO4)=CC=C5)=N1
Molecular Formula
C23H23N5O
Molecular Weight
385.46
References & Citations
[1]Liang H, et al. Designing Macrocyclic Kinase Inhibitors Using Macrocycle Scaffold Hopping with Reinforced Learning (Macro-Hop) . J Med Chem. 2025 Mar 27;68 (6) :6698-6717.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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