YJZ5118

YJZ5118 is a CDK12/13 inhibitor with IC50 values of 39.5 nM and 26.4 nM against CDK12 and CDK13, respectively. By inducing DNA damage and Apoptosis, YJZ5118 effectively suppresses tumor cell proliferation and exhibits synergistic effects with Akt inhibitors. YJZ5118 can be used for research in the field of cancer[1].

Product Specifications

CAS Number

[3031861-18-1]

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

C=CC(NC1=CC(N(C(NCC2=CC=CC=C2)=O)[C@H]3CC[C@@H](CC3)NC4=NC=C(C=C4)C#N)=CC=C1N5CCC(CC5)N(C)C)=O

Molecular Formula

C36H44N8O2

Molecular Weight

620.79

References & Citations

[1]Yang J, et al. Discovery of YJZ5118: A Potent and Highly Selective Irreversible CDK12/13 Inhibitor with Synergistic Effects in Combination with Akt Inhibition. J Med Chem. 2025 Mar 27;68 (6) :6718-6734.