BT-114143

BT-114143 is a plasminogen activation inhibitor, with an IC50 of 8.42 μM. BT-114143 can be used in the research of hemorrhagic diseases caused by hyperfibrinolysis, such as traumatic bleeding, severe menstrual bleeding, postpartum hemorrhage, and complications of hemophilia[1].

Product Specifications

CAS Number

2796343-04-7

UNSPSC

12352005

Target

PAI-1

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=P(O)(C1=CC=C(CNCC2)C2=N1)O

Molecular Formula

C8H11N2O3P

Molecular Weight

214.16

References & Citations

[1]Ji S, et al. Discovery of BT-114143, a Novel and Potent Phosphoric Acid-Containing Small-Molecule Plasminogen Activation Inhibitor for Hyperfibrinolysis. J Med Chem. 2025 Mar 27;68 (6) :6084-6099.