GHSR-1a agonist-1

GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a), with an EC50 of 0.49 nM. GHSR-1a agonist-1 can effectively stimulate the release of endogenous growth hormone by activating GHSR-1a. GHSR-1a agonist-1 administered orally at a dose as low as 0.1 mg/kg can increase the body weight and body length of 4-week-old rats. GHSR-1a agonist-1 can be used in the research field of growth and development retardation in children[1].

Product Specifications

CAS Number

[3060887-25-1]

UNSPSC

12352005

Target

GHSR

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Smiles

O=C(N(CCC1=NN(C2=O)C3CC3)C[C@]12CC4=CC=CC=C4)[C@@H](COCC5=CC=CC=C5)NC(C(N)(C)C)=O

Molecular Formula

C30H37N5O4

Molecular Weight

531.65

References & Citations

[1]Xu H, et al. Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency. J Med Chem. 2025 Mar 27;68 (6) :6766-6788.