CypB-IN-1
CypB-IN-1 (Compound 11) is an inhibitor of cyclophilin B (cyclophilin B) with a Kd value of 12 nM. CypB-IN-1 can be applied to the research field of metabolic dysfunction-associated steatohepatitis (MASH) and the liver fibrosis diseases resulting from it[1].
Product Specifications
UNSPSC
12352005
Target
Cyclophilin
Related Pathways
Immunology/Inflammation
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(NCC(N1[C@@H](C2=CC=CC=C2SC)CCC1)=O)N(CC3=CC=C(N)C(Cl)=C3)CC4=NN(C)N=N4
Molecular Formula
C24H29ClN8O2S
Molecular Weight
529.06
References & Citations
[1]Kouridaki ME, et al. Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments. J Med Chem. 2025 Mar 27;68 (6) :6815-6831.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin B
Curated Selection
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