AChE-IN-86

AChE-IN-86 (Compound 6f) is an inhibitor of enzyme acetylcholinesterase (AChE) with IC50 values of 25.33 μg/mL. AChE-IN-86 exerts inhibitory activity against AChE through forming hydrogen bonds, π-π and π-alkyl interactions with amino acid residues at the key catalytic sites of AChE. AChE-IN-86 can be used for Alzheimer's disease study[1].

Product Specifications

CAS Number

[3078693-67-8]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(OC)=O)COC2=C(OC)C=C(C3=NC4=CC=CC=C4S3)C=C2NC(C)=O

Molecular Formula

C28H27N3O6S

Molecular Weight

533.60

References & Citations

[1]Nguyen DD, et al. Synthesis, Formation Mechanisms, and Molecular Dynamics Simulation of Novel Benzothiazole and Benzo[1,4]oxazin-3 (4H) -one as Potential Acetylcholinesterase Inhibitors. ACS Omega. 2025 Mar 10;10 (11) :10835-10851.