AChE-IN-86
AChE-IN-86 (Compound 6f) is an inhibitor of enzyme acetylcholinesterase (AChE) with IC50 values of 25.33 μg/mL. AChE-IN-86 exerts inhibitory activity against AChE through forming hydrogen bonds, π-π and π-alkyl interactions with amino acid residues at the key catalytic sites of AChE. AChE-IN-86 can be used for Alzheimer's disease study[1].
Product Specifications
CAS Number
3078693-67-8
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(OC)=O)COC2=C(OC)C=C(C3=NC4=CC=CC=C4S3)C=C2NC(C)=O
Molecular Formula
C28H27N3O6S
Molecular Weight
533.60
References & Citations
[1]Nguyen DD, et al. Synthesis, Formation Mechanisms, and Molecular Dynamics Simulation of Novel Benzothiazole and Benzo[1,4]oxazin-3 (4H) -one as Potential Acetylcholinesterase Inhibitors. ACS Omega. 2025 Mar 10;10 (11) :10835-10851.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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