DAO-dBET1
DAO-dBET1 is a Dual-Action-Only PROTAC containing a PROTAC degrader, dBET1. DAO-dBET1 is a potent BRD4 degrader with a DC50 value of 277 nM in the presence of CoCl2. DAO-dBET1 inhibits hypoxia and Cath-L trigger with an IC50 value of 281 nM[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[C@H]3CC(N(CC4=CC=C([N+]([O-])=O)C=C4)CCCCN(C(COC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CC8=CC=C(NC([C@@H](NC(OC(C)(C)C)=O)CCCCNC(C)=O)=O)C=C8)=O)=C(S1)N9C3=NN=C9C
Molecular Formula
C65H71ClN12O13S
Molecular Weight
1295.85
References & Citations
[1]Ranit Dutta, et al. Dual-Action-Only PROTACs. J Am Chem Soc. 2025 Mar 19;147 (11) :9074-9078.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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