KRASG12C ligand-1

KRASG12C ligand-1 is a PROTAC target protein ligand that can be used to synthesize the PROTAC YN14-H (HY-173250) . YN14-H is a PROTAC degrader targeting KRASG12C and has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(C=CC=C4OCC5CCNCC5)F)=C(F)C=C3C(N6[C@@H](C)CN(C(C=C)=O)CC6)=N1

Molecular Formula

C36H41F2N7O3

Molecular Weight

657.75

References & Citations

[1]Sun S, et al. Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation. Chinese Chemical Letters, 2025: 110992.