ENX-101
ENX-101 is an orally active (GABAA) receptor partial positive allosteric modulator (PAM) . ENX-101 is selective to α2β2γ2L (EC50 = 0.76 nM), α2β3γ2L (EC50 = 0.61 nM), α3 (EC50 = 1.97 nM), α5 (EC50 = 0.85 nM) subunits of GABA receptor. ENX-101 possesses antiseizure activity in several animal models[1].
Product Specifications
UNSPSC
12352005
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
FC1=CC=C(F)C=C1C2=NN=C3N2N=C(OCC4=NC=NN4C)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C3.O
Molecular Formula
C19H12D9F2N7O2
Molecular Weight
426.47
References & Citations
[1]Serrats J, et al., ENX-101, a GABAA receptor α2,3,5-selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models. Epilepsia. 2025 Mar 15.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173251S/
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 2
Curated Selection
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