YN14-H
YN14-H is a PROTAC degrader targeting KRASG12C. YN14-H inhibits cell growth in NCI-H358 and MIA PaCa-2 cells (IC50 values of 0.042, 0.021 μM, DC50 values of 28.9, 18.1 nM, respectively) . YN14-H significantly induces apoptosis and inhibits migration. YN14-H demonstrates favorable pharmacokinetic properties and excellent antitumor activity in vivo. (Structure Note: Pink: target protein ligand (HY-173252) ; Blue: E3 ligase ligand (HY-125905) ; Black: linker (HY-Y0840) ; E3 ligase ligand + linker (HY-173253) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PROTACs; Ras
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
Molecular Formula
C65H78F3N11O8S
Molecular Weight
1230.44
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-173250/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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