Val-Ala-PAB-SN38 (TFA)
Val-Ala-PAB-SN38 TFA is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) [1].
Product Specifications
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Purity
98.22
Solubility
DMSO : 100 mg/mL
Smiles
O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC=C4O)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](C)NC([C@@H](N)C(C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C40H42F3N5O11
Molecular Weight
825.78
References & Citations
[1]Paul Joseph Mark JACKSON, et al. Antibody-drug conjugates. WO2024013724A1. 2023-07-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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