Val-Ala-PAB-SN38

Val-Ala-PAB-SN38 is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) [1].

Product Specifications

CAS Number

[3025787-76-9]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC=C4O)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](C)NC([C@@H](N)C(C)C)=O)=O)=O)=O

Molecular Formula

C38H41N5O9

Molecular Weight

711.76

References & Citations

[1]Paul Joseph Mark JACKSON, et al. Antibody-drug conjugates. WO2024013724A1. 2023-07-15

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Curated Selection

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