Antibacterial agent 274
Antibacterial agent 274 (Compound 18b) is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 μg/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
C[N+]1(CCCCCCCCCCCC)CCN(C([C@]([H])(C2=CC(O)=CC(O)=C23)NC([C@@]4([H])NC([C@]([H])(NC([C@@H](C5=CC(OC(C=C6)=C(Cl)C=C6[C@H]7O)=C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O[C@@H]9O[C@@H](C)[C@@H](O)[C@](N)(C)C9)C(OC(C=C%10)=C(Cl)C=C%10[C@H]4O)=C5)NC([C@H](CC(N)=O)NC([C@@H]7NC([C@@H](CC(C)C)NC)=O)=O)=O)=O)C%11=CC3=C(O)C=C%11)=O)=O)=O)CC1.[Br-]
Molecular Formula
C83H110BrCl2N11O23
Molecular Weight
1780.63
References & Citations
[1]Li T, et al. Synthesis and antibacterial evaluations of novel vancomycin analogues targeting bacteria membrane to combat Gram-negative infections. Eur J Med Chem. 2025 May 5;289:117483.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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