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Antibacterial agent 273

Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS) . Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

O=C(N[C@@H]1C(N2[C@@H]1SCC(C[N+]3=CC=C(C4=CC=[N+](CCCCCCCCCCCCCCCC)C=C4)C=C3)=C2C([O-])=O)=O)CC5=CC=CC=C5.FC(F)(F)C([O-])=O

Molecular Formula

C44H55F3N4O6S

Molecular Weight

824.99

References & Citations

[1]Chen S, et al. Exploration of membrane-active cephalosporin derivatives as potent antibacterial agents against Staphylococcus aureus biofilms and persisters. Eur J Med Chem. 2025 May 5;289:117484.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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