CDK4/6/BRD4-IN-1

CDK4/6/BRD4-IN-1 (B15) is an inhibitor of CDK4, CDK6 and BRD4, with IC50 values of 220 nM, 146 nM, 106 nM and 85 nM for BRD4-BD2, BRD4-BD1, CDK6 and CDK4, respectively. CDK4/6/BRD4-IN-1 (B15) can be used in the study of NSCLC (Non-Small Cell Lung Cancer) . CDK4/6/BRD4-IN-1 (B15) induces cell cycle arrest and apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

CDK; Epigenetic Reader Domain

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C(C1=CC2=CN=C(NC3=NC=C(N4CCN(C(COC5=C(OC)C=C(C(N6)=NC7=C(C=C(F)C=C7)C6=O)C=C5OC)=O)CC4)C=C3)N=C2N1C8CCCC8)N(C)C

Molecular Formula

C41H43FN10O6

Molecular Weight

790.84

References & Citations

[1]Yonglei Zhang, et al. Discovery of dual CDK4/6 and BRD4 inhibitor as apoptosis and autophagy inducers against NSCLC in vitro and in vivo. Eur J Med Chem. 2025 Jun 5:290:117495.