Galectin-3-IN-6

Galectin-3-IN-6 (Compound 12) is an orally active inhibitor of galectin-3 (Gal-3), with an IC50 value of 12 nM and a Kd value of 13 nM for Gal-3. In a mouse model of acute liver injury and fibrosis induced by CCl4, Galectin-3-IN-6 can significantly reduce the levels of fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, showing significant anti-fibrotic activity. Galectin-3-IN-6 can be used in the research of fibrotic diseases, cancer, and cardiovascular diseases[1].

Product Specifications

CAS Number

[2604662-64-6]

UNSPSC

12352005

Target

Galectin

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Smiles

FC1=C(F)C(F)=CC(C2=CN([C@@H]3[C@@H](OC)[C@H](C(N(C4=CC(Cl)=CC(Cl)=C4)[C@@H]5[C@@H](O)CCCC5)=O)O[C@H](CO)[C@@H]3O)N=N2)=C1

Molecular Formula

C28H29Cl2F3N4O6

Molecular Weight

645.45

References & Citations

[1]Zumbrunn C, et al. Discovery of Galactopyranose-1-carboxamides as a New Class of Small, Novel, Potent, Selective, and Orally Active Galectin-3 Inhibitors. ChemMedChem. 2025 Mar 12:e202401012.