GI-Y2
GI-Y2 is an inhibitor of GSDMD and can inhibit Pyroptosis of macrophages induced by oxidized low-density lipoprotein (ox-LDL) . In vivo, GI-Y2 can dose-dependently reduce atherosclerotic plaques in ApoE-/- mice and decrease the lesion size and fibrosis degree of the aortic root. GI-Y2 is expected to be used in the research of pyroptosis and cardiovascular diseases, such as atherosclerosis[1].
Product Specifications
CAS Number
[1008710-58-4]
UNSPSC
12352005
Target
Pyroptosis
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cardiovascular Disease
Smiles
OC(C1=CC=C(CN2C(SC(NC3=CC=C(C(O)=O)C=C3)C2=O)=O)C=C1)=O
Molecular Formula
C18H14N2O6S
Molecular Weight
386.38
References & Citations
[1]Fan X, et al. The novel GSDMD inhibitor GI-Y2 exerts antipyroptotic effects to reduce atherosclerosis. Clin Transl Med. 2025 Mar;15 (3) :e70263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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