PLK1-IN-14
PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor. It has an IC50 of 22.61 pM against PLK1 and an IC50 of 0.09 nM for inhibiting the proliferation of DU - 145 prostate cancer cells. PLK1-IN-14 can be used in the research of prostate cancer[1].
Product Specifications
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
COC1=CC(C(NC2CCC(N3CCN(C[C@H]4CCC5(CCCC5)C4)CC3)CC2)=O)=C(F)C=C1NC6=NC=C(N(C)C(C(F)(F)CN7[C@H]8CCCC8(F)F)=O)C7=N6
Molecular Formula
C41H55F5N8O3
Molecular Weight
802.92
References & Citations
[1]Xu Z, et al. Discovery of a novel PLK1 inhibitor with high inhibitory potency using a combined virtual screening strategy. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2467798.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK1
Curated Selection
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