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PLK1-IN-14

PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor. It has an IC50 of 22.61 pM against PLK1 and an IC50 of 0.09 nM for inhibiting the proliferation of DU - 145 prostate cancer cells. PLK1-IN-14 can be used in the research of prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

Polo-like Kinase (PLK)

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

COC1=CC(C(NC2CCC(N3CCN(C[C@H]4CCC5(CCCC5)C4)CC3)CC2)=O)=C(F)C=C1NC6=NC=C(N(C)C(C(F)(F)CN7[C@H]8CCCC8(F)F)=O)C7=N6

Molecular Formula

C41H55F5N8O3

Molecular Weight

802.92

References & Citations

[1]Xu Z, et al. Discovery of a novel PLK1 inhibitor with high inhibitory potency using a combined virtual screening strategy. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2467798.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PLK1

Frequently Asked Questions

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