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VEGFR-2-IN-66

VEGFR-2-IN-66 (Compound 6) is an orally active VEGFR-2 inhibitor with an IC50 value of 0.509 µM and an IC50 value of 7.48 μM for inhibiting the proliferation of MCF-7 cells. VEGFR-2-IN-66 exerts its anti-cancer activity by arresting the cell cycle, inducing apoptosis, and regulating gene expression, and can be used in the research of the breast cancer field[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; VEGFR

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC1CCC(NC1=O)=O)CN(CC2)CCN2C3=NC4=CC=CC=C4C5=NN=CN35

Molecular Formula

C20H22N8O3

Molecular Weight

422.44

References & Citations

[1]Mabrouk RR, et al. Novel triazoloquinazoline derivatives as VEGFR inhibitors: synthesis, cytotoxic evaluation and in silico studies. Future Med Chem. 2025 Mar;17 (5) :529-541.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

Frequently Asked Questions

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