HURAT1 inhibitor 2
HURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. hURAT1 inhibitor 2 also has a certain inhibitory effect on OATP1B1, with an IC50 value of 0.73 μM. hURAT1 inhibitor 2 can be used in the research of diseases related to abnormal uric acid metabolism, such as hyperuricemia and gout[1].
Product Specifications
CAS Number
[1402818-99-8]
UNSPSC
12352005
Target
URAT1
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease
Smiles
O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC(F)=CC=C23
Molecular Formula
C17H11Br2FO3
Molecular Weight
442.07
References & Citations
[1]Jutabha P, et al. Benzbromarone Analog SAR: Potent hURAT1 (SLC22A12) Inhibitors and Drug Transporter Interaction Studies. Drug Des Devel Ther. 2025 Feb 26;19:1377-1392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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