ABCA1 inducer 2
ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential[1].
Product Specifications
CAS Number
2451589-46-9
UNSPSC
12352005
Target
ATP-binding cassette (ABC) transporters; LXR
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cardiovascular Disease
Purity
98.22
Smiles
O=C1N(CCC2=C3C=CC=C2)C3=NC4=C1C(Br)=CC=C4
Molecular Formula
C16H11BrN2O
Molecular Weight
327.18
References & Citations
[1]Yang C, et al. Synthesis and evaluation of 5, 6-dihydro-8H-isoquinolino[1, 2-b]quinazolin-8-one derivatives as novel non-lipogenic ABCA1 up-regulators with inhibitory effects on macrophage-derived foam cell formation. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2470310.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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