ABCA1 inducer 2

ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential[1].

Product Specifications

CAS Number

[2451589-46-9]

UNSPSC

12352005

Target

ATP-binding cassette (ABC) transporters; LXR

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cardiovascular Disease

Purity

98.22

Smiles

O=C1N(CCC2=C3C=CC=C2)C3=NC4=C1C(Br)=CC=C4

Molecular Formula

C16H11BrN2O

Molecular Weight

327.18

References & Citations

[1]Yang C, et al. Synthesis and evaluation of 5, 6-dihydro-8H-isoquinolino[1, 2-b]quinazolin-8-one derivatives as novel non-lipogenic ABCA1 up-regulators with inhibitory effects on macrophage-derived foam cell formation. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2470310.