TrkC-IN-1

TrkC-IN-1 (Compound 6c) is an inhibitor of TrkC. The IC50 values for EBC-1 and HT-29 cells are 3.3-7.1 and 7.3-10.2 μΜ, respectively. TrkC-IN-1 is expected to be used in the research of the anti-cancer field[1].

Product Specifications

CAS Number

[1877313-32-0]

UNSPSC

12352005

Target

Trk Receptor

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

BrC1=CC=C(CN2C3=CC=CC=C3C4(C2=O)C5=C(OC(N)=C4C#N)N(C6=CC=CC=C6)N=C5C)C=C1

Molecular Formula

C28H20BrN5O2

Molecular Weight

538.39

References & Citations

[1]Mohammadi S, et al. Novel spiroisatin-pyranopyrazole hybrids as anticancer agents with TrkC inhibitory potential. J Biomol Struct Dyn. 2025 Mar 2:1-14.