BACE1-IN-15
BACE1-IN-15 (Compound 72) is a selective inhibitor of beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) with oral activity and the ability to penetrate the blood-brain barrier. Its IC50 value is 121.65 nM (the IC50 value for BACE-2 is 480.92 nM) . BACE1-IN-15 can be used in the research of the Alzheimer's disease field[1]
Product Specifications
UNSPSC
12352005
Target
Beta-secretase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC1=C(C(NC2=CC(SC(N)=N3)=C3C=C2)=O)C=CC(F)=C1OC
Molecular Formula
C15H11F2N3O2S
Molecular Weight
335.33
References & Citations
[1]Afzal O, et al. Rational design, docking, simulation, synthesis, and in vitro studies of small benzothiazole molecules as selective BACE1 inhibitors. J Biomol Struct Dyn. 2025 Mar 2:1-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3450106 1.0 µg DNA
Bag4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details RC220452L1V 200 µL
LILRA4 (NM_012276) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details MBS1240196-01 0.02 mg (E-Coli)
Recombinant Cryptococcus neoformans var. neoformans serotype D 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
Sign In for Pricing
View Details