BACE1-IN-15
BACE1-IN-15 (Compound 72) is a selective inhibitor of beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) with oral activity and the ability to penetrate the blood-brain barrier. Its IC50 value is 121.65 nM (the IC50 value for BACE-2 is 480.92 nM) . BACE1-IN-15 can be used in the research of the Alzheimer's disease field[1]
Product Specifications
UNSPSC
12352005
Target
Beta-secretase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
FC1=C(C(NC2=CC(SC(N)=N3)=C3C=C2)=O)C=CC(F)=C1OC
Molecular Formula
C15H11F2N3O2S
Molecular Weight
335.33
References & Citations
[1]Afzal O, et al. Rational design, docking, simulation, synthesis, and in vitro studies of small benzothiazole molecules as selective BACE1 inhibitors. J Biomol Struct Dyn. 2025 Mar 2:1-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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