P-gp inhibitor 28
P-gp inhibitor 28 (Compound 4h) is an inhibitor targeting P-glycoprotein (P-gp) . It can inhibit the proliferation of cancer cells, and its IC50 value for MCF-7/ADR cells is between 15.88 and 21.96 μM. P-gp inhibitor 28 can increase the accumulation of Rho123 in MCF-7/ADR cells and can be used in research related to cancer and overcoming multidrug resistance in tumors[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
O=C1OC2=CC=C(C)C=C2C3=C1C(C4=CC=C(OCC5=CC=CC=C5)C=C4)C(C#N)=C(N)O3
Molecular Formula
C27H20N2O4
Molecular Weight
436.46
References & Citations
[1]Helal MH, et al. Unraveling the interaction of pyranocoumarins with P-glycoprotein: Implications for overcoming multidrug resistance in cancer therapy. Bioorg Chem. 2025 May;158:108314.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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