MJ210
MJ210 is a modulator of the NF-κB and MAPK pathways with oral activity and the ability to penetrate the blood-brain barrier, and it exhibits neuroprotective activity. In vitro, 5 μM of MJ210 can increase the survival rate of SH-SY5Y cells treated with Rotenone to 81.9% and reduce the level of ROS, etc. In vivo, 5 mg/kg of MJ210 can improve the motor impairment in a rat model of Parkinson's disease. MJ210 can be used in the research of neurological diseases, such as Parkinson's disease[1].
Product Specifications
UNSPSC
12352005
Target
NF-κB; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Neurological Disease
Smiles
O=C(OC1=C(OC)C=C(CCC(N2CCCCC2)=O)C=C1OC)C3=NC=CC=C3
Molecular Formula
C22H26N2O5
Molecular Weight
398.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD63 (MX-49.129.5), CF640R conjugate, 0.1mg/mL
Human IgG Immunoglobulin (IG266), CF488A conjugate, 0.1mg/mL
Human IgG Immunoglobulin (IG266), CF594 conjugate, 0.1mg/mL
CD54 / ICAM-1 (15.2), CF568 conjugate, 0.1mg/mL
