DHFR-IN-23
DHFR-IN-23 (compound 5) is a dual DNA binders/DHFR inhibitor, with an IC50 of 0.08 μM for hDHFR. DHFR-IN-23 (compound 5) is also an apoptosis inducer. DHFR-IN-23 (compound 5) can be used for the research of ER+ breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Dihydrofolate reductase (DHFR)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(O)C(/C=C/C1=CC=C(Cl)C=C1)=N\NC2=NC(C3=CC=CC=C3)=CS2
Molecular Formula
C19H14ClN3O2S
Molecular Weight
383.85
References & Citations
[1]Marwa H, et al. Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry Volume 40, 2025 - Issue 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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